CE - PowerPak - Overactive Bladder

Two drug classes are for treating Overactive Bladder (OAB) per AUA

• Antimuscarinic agents
• Older
• Oxybutynin (DITROPAN XL, OXYTROL; available = Oxytrol Patch (twice weekly), 5mg tab;  5, 10, 15 XL tab, approved by FDA 1988)
• Side Effects (marked anti-cholinergic effects everywhere)
• CNS
• somnolence / confusion / dizziness
• GI
• Dry mouth / constipation
• CV
• Tachycardia / arrhythmia
• Tolterodine (DETROL / available = 1,2mg IR tab; 2, 4mg LA cap / FDA 1998)
• Newer
• 

• ENABLEX (DARIfenacin / available = 7.5, 15mg / FDA 2004) 
• TOVIAZ (FESOterodine / available = 4, 8mg / FDA 2008) 
• TROspium (SANCTURA / available = 20mg IR tab, 60mg XR cap / FDA 2004) 
• 
• VESICARE (SOLIfenacin / available = 5, 10mg / FDA 2004) 
• Beta 3 adrenergic agonist
• 
• MYRBETRIQ (MIRAbegron / available = 25, 50mg / FDA 2012) 
• Side Effects
• CV
• Increased BP / palpitation
• CNS
• Dizziness