Opioid Med Flyer for patient

This is a pdf file from Mendocino county opioid coalition. It's meant for patients. It makes me wonder about its claim:

Side Effects of Opioids include these following peculiar ones:

• Loss of strength
• Decreased sex drive
• Infertility
• Low testosterone in males
• More pain and pain sensitivity
• Compromised Immune System
• Memory loss

How in the world do I explain these side effects??